The following link is to an abstract of the original article describing the genetic aberration associated with Fragile X syndrome. http://www.ncbi.nlm.nih.gov/pubmed/2031184
This NY Times article says that Novartis, a Swiss drug company, is developing a drug that helps improve behavior of adults affected with Fragile X. Unfortunately, the drug is in its very preliminary stages. The article also talks about the history and general information about Fragile X. http://www.nytimes.com/2010/04/30/health/research/30fragile.html
Katie Clapp, the executive director of the FRAXA Research Foundation, will be with us at the symposium addressing Fragile X. She is the mother of a kid with Fragile X and has made amazing contributions to promote research as a founder and director of an advocacy group. See a link to the foundation: http://www.fraxa.org/
Stephen Haggarty, has confirmed his participation in our symposium on Fragile X. Dr. Haggarty is Harvard faculty and director of chemical biology at the Broad Institute. He has extensive experience on drug development to modulate neuronal circuits like those affected in Fragile X. See a link to his lab website.
21 Comments
Joseph Fitzgerald Arboleda-Velasquez
In this video the strong links between fragile X syndrome and autism are discussed in a lecture format. http://www.youtube.com/watch?v=9lcu_SAz9WE&feature=relmfu
Joseph Fitzgerald Arboleda-Velasquez
The following link is to an abstract of the original article describing the genetic aberration associated with Fragile X syndrome. http://www.ncbi.nlm.nih.gov/pubmed/2031184
Jill Penn
Here is a link to a segment that aired on NPR about a potential drug treatment for Fragile X syndrome. http://www.npr.org/templates/story/story.php?storyId=94810949
Anindya Kumar Sen
Real Life stories of patients
http://www.youtube.com/watch?v=-6-J_YcVRi4
Anindya Kumar Sen
Care:
http://www.wellness.com/reference/conditions/fragile-x-syndrome-fxs/prevention-and-treatment
Christian R. Schubert
Some interesting facts comparing and linking Fragile X syndrome and Autism Spectrum Disorders:
http://www.fragilex.org/html/autism_and_fragile_x_syndrome.htm
Christian R. Schubert
One of the world's leading Fragile X research labs - The Warren Laboratory at Emory University School of Medicine:
http://genetics.emory.edu/labs/index.php?link=Home&lab=22&page=106
Krystal Loo-tien Tung
This NY Times article says that Novartis, a Swiss drug company, is developing a drug that helps improve behavior of adults affected with Fragile X. Unfortunately, the drug is in its very preliminary stages. The article also talks about the history and general information about Fragile X. http://www.nytimes.com/2010/04/30/health/research/30fragile.html
Also, this website shows more about the study that Novartis is running. http://www.clinicaltrials.gov/ct2/show/NCT01253629?term=fragile+x&rank=1
Joseph Fitzgerald Arboleda-Velasquez
Katie Clapp, the executive director of the FRAXA Research Foundation, will be with us at the symposium addressing Fragile X. She is the mother of a kid with Fragile X and has made amazing contributions to promote research as a founder and director of an advocacy group. See a link to the foundation: http://www.fraxa.org/
Joseph Fitzgerald Arboleda-Velasquez
Stephen Haggarty, has confirmed his participation in our symposium on Fragile X. Dr. Haggarty is Harvard faculty and director of chemical biology at the Broad Institute. He has extensive experience on drug development to modulate neuronal circuits like those affected in Fragile X. See a link to his lab website.
http://chemicalbiology.mgh.harvard.edu/labs-haggarty.htm
Anindya Kumar Sen
Fmr1 and fruitflies
http://www.sciencedaily.com/releases/2008/03/080309151235.htm
Angela Sara Frankel
A discussion of model organisms, including similarities in wildtype function of corresponding gene, and similarities in mutation:
http://dmm.biologists.org/content/3/11-12/693.full.pdf+html.
[Fragile X syndrome and model organisms: identifying potential routes of therapeutic intervention]
Vivian Betty Ling
Description of how the FMRP protein's role in translation and with miRNAs
http://www.nature.com/neuro/journal/v7/n2/full/nn1174.html
Vivian Betty Ling
This review might also be useful - A decade of molecular studies of fragile X syndrome.
http://www.ncbi.nlm.nih.gov/pubmed/12052912?dopt=Abstract&holding=npg
Josephine Volovetz
Here's an abstract that discusses a model organism and how it illustrates the normal functions of FMR-1
http://www.ncbi.nlm.nih.gov/pubmed/8490651
Daniel Keo Okubo
Another article about using mice as a model organism.
http://www.ncbi.nlm.nih.gov/pubmed/8033209
Sandrine Umutoni Uwimana
The lab results regarding Fragile X were useful for looking at the mutations in relation to the functional domain. Also, just good information.
http://www.aruplab.com/Testing-Information/resources/TechnicalBulletins/Fragile%20X.pdf
Shanna Mary Wiggins
This mini review summarizes many studies' findings on the function of the FMR1 gene:
http://onlinelibrary.wiley.com.ezp-prod1.hul.harvard.edu/doi/10.1034/j.1399-0004.2001.600601.x/pdf
Rachel Erica Davidson
This abstract is helpful in identifying a successful pharmaceutical treatment for FXTAS in male permutation carriers.
http://www.ncbi.nlm.nih.gov/pubmed/19471185
Lauren Jenelle Tomkinson
this link is helpful for identifying FMR1 domains.
http://www.nature.com.ezp-prod1.hul.harvard.edu/ng/journal/v3/n1/abs/ng0193-36.html
Krystal Loo-tien Tung
Fragile X handout:
Fragile X.pdf